Determination of Bias in the Relative Abundance of Oligonucleotides in DNA Sequences

  title={Determination of Bias in the Relative Abundance of Oligonucleotides in DNA Sequences},
  author={Jeff Elhai},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={8 2},
Different statistical measures of bias of oligonucleotide sequences in DNA sequences were compared, both by theoretical analysis and according to their abilities to predict the relative abundances of oligonucleotides in the genome of Escherichia coli. The expected frequency of an oligonucleotide calculated from a maximal order Markov model was shown to be a degenerate case of the expected frequency calculated from biases of all subwords arising when noncontiguous subwords exhibit no bias. Since… CONTINUE READING

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