Determination of Absolute Orientation of Protein α-Helices at Interfaces Using Phase-Resolved Sum Frequency Generation Spectroscopy.

@article{Schmueser2017DeterminationOA,
  title={Determination of Absolute Orientation of Protein α-Helices at Interfaces Using Phase-Resolved Sum Frequency Generation Spectroscopy.},
  author={Lars Schmueser and Steven J Roeters and Helmut Lutz and Sander Woutersen and Tobias Weidner and Lars Schm{\"u}ser and Mischa Bonn},
  journal={The journal of physical chemistry letters},
  year={2017},
  volume={8 13},
  pages={
          3101-3105
        }
}
Understanding the structure of proteins at surfaces is key in fields such as biomaterials research, biosensor design, membrane biophysics, and drug design. A particularly important factor is the orientation of proteins when bound to a particular surface. The orientation of the active site of enzymes or protein sensors and the availability of binding pockets within membrane proteins are important design parameters for engineers developing new sensors, surfaces, and drugs. Recently developed… CONTINUE READING
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