Determination of 2-chloro-2'-deoxyadenosine in human plasma.

  title={Determination of 2-chloro-2'-deoxyadenosine in human plasma.},
  author={Jan O Liliemark and Birgitta Pettersson and Gunnar Juliusson},
  journal={Biomedical chromatography : BMC},
  volume={5 6},
The first high performance liquid chromatographic method for determination of the plasma concentration of 2-chloro-2'-deoxyadenosine (CdA) in patients, which is significantly more sensitive than the previously used RIA method, is presented. CdA is a purine analogue with useful clinical activity against lymphoproliferative disorders and it has recently been found to be the single most active agent in the treatment of hairy cell leukaemia. Guaneran (6-nitroimidazol-6-thioguanine) was added to 1… CONTINUE READING


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