Determination and pharmacokinetics of acyclovir after ingestion of suspension form.

  title={Determination and pharmacokinetics of acyclovir after ingestion of suspension form.},
  author={A. Jankowski and A. Jankowska and H. Lamparczyk},
  journal={Journal of pharmaceutical and biomedical analysis},
  volume={18 1-2},
The study describes, simple, precise, sensitive and accurate HPLC assay with spectrofluorimetric detection for the determination of acyclovir in human plasma. The method was linear over a range 25 1200 ng ml(-1). The average yield in this method exceeded 80%. Limits of quantitation and detection were 25 and 10 ng ml(-1), respectively. On the basis of reported method, a single-dose of pharmacokinetics on 24 men, in two doses (200 and 400 mg) of acyclovir suspension has been investigated… Expand

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