Determination and pharmacokinetics of a furosemide-amiloride drug combination.

@article{Jankowski1997DeterminationAP,
  title={Determination and pharmacokinetics of a furosemide-amiloride drug combination.},
  author={A. Jankowski and A. Skorek-Jankowska and H. Lamparczyk},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1997},
  volume={693 2},
  pages={
          383-91
        }
}
The study presents an accurate and precise HPLC assay for the determination of furosemide and amiloride in human specimens. Both drugs were extracted from human plasma with ethyl acetate; furosemide was extracted at pH 1 and amiloride at pH 12. While chromatographic separation conditions, i.e., column, mobile phase and flow-rate were the same for both investigated drugs, furosemide was detected using a UV absorbance detector, whereas amiloride, because of its very low therapeutic range, was… Expand
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