Determination and pharmacokinetic study of two triterpenoid saponins in rat plasma after oral administration of the extract of Aralia elata leaves by UHPLC-ESI-MS/MS.

@article{Wang2015DeterminationAP,
  title={Determination and pharmacokinetic study of two triterpenoid saponins in rat plasma after oral administration of the extract of Aralia elata leaves by UHPLC-ESI-MS/MS.},
  author={Zhi-bin Wang and Qiong Wu and Yonghai Meng and Yichun Sun and Qi Wang and Chunjuan Yang and Qiuhong Wang and Bing-you Yang and Hai-Xue Kuang},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2015},
  volume={985},
  pages={164-71}
}
Aralia elata (Miq.) Seems (A. elata) grow in Northeast China and the total saponins of A. elata is used to auxiliary treatment for the acute hepatitis, chronic hepatitis and the transaminase on the high side. Aralia-saponinV and Aralia-saponinVI are the major bioactive saponins in A. elata leaves. A selective and sensitive UHPLC-MS/MS method was developed and validated for the determination and pharmacokinetic study of Aralia-saponinV and Aralia-saponinVI indwelling the extract in rat plasma in… CONTINUE READING

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