Determination and metabolism of dithiol chelating agents. III. Formation of oxidized metabolites of 2,3-dimercaptopropane-1-sulfonic acid in rabbit.

@article{Maiorino1988DeterminationAM,
  title={Determination and metabolism of dithiol chelating agents. III. Formation of oxidized metabolites of 2,3-dimercaptopropane-1-sulfonic acid in rabbit.},
  author={Richard M Maiorino and George L Weber and H. Vasken Aposhian},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1988},
  volume={16 3},
  pages={455-63}
}
Disulfide metabolites of 2,3-dimercaptopropane-1-sulfonic acid (DMPS), a heavy metal chelating agent, have been found in the urine of catheterized rabbits after a single dose of DMPS. After treating the urine with a reducing agent such as NaBH4, a 20-fold increase in DMPS was observed within 6 hr after administration. This suggested the presence of… CONTINUE READING