Determinants of voltage-gated sodium channel clustering in neurons.

  title={Determinants of voltage-gated sodium channel clustering in neurons.},
  author={Christophe Leterrier and Anna Brachet and B{\'e}n{\'e}dicte Dargent and H{\'e}l{\`e}ne Vacher},
  journal={Seminars in cell & developmental biology},
  volume={22 2},
In mammalian neurons, the generation and propagation of the action potential result from the presence of dense clusters of voltage-gated sodium channels (Nav) at the axonal initial segment (AIS) and nodes of Ranvier. In these two structures, the assembly of specific supra-molecular complexes composed of numerous partners, such as cytoskeletal scaffold proteins and signaling proteins ensures the high concentration of Nav channels. Understanding how neurons regulate the expression and discrete… CONTINUE READING
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