Determinants of virulence of classical swine fever virus strain Brescia.

@article{Gennip2004DeterminantsOV,
  title={Determinants of virulence of classical swine fever virus strain Brescia.},
  author={H. G. P. van Gennip and A Corina Vlot and Marcel Hulst and Abraham J. de Smit and Rob J. M. Moormann},
  journal={Journal of virology},
  year={2004},
  volume={78 16},
  pages={
          8812-23
        }
}
Two related classical swine fever virus (CSFV) strain Brescia clones were isolated from blood samples from an infected pig. Virus C1.1.1 is a cell-adapted avirulent variant, whereas CoBrB is a virulent variant. Sequence analysis revealed 29 nucleic acid mutations in C1.1.1, resulting in 9 amino acid substitutions compared to the sequence of CoBrB (476)R. Using reverse genetics, parts of the genomes of these viruses, which contain differences that lead to amino acid changes, were exchanged… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Correlation of the virulence of CSFV with evolutionary patterns of E2 glycoprotein.

  • Frontiers in bioscience
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED