Determinants of vascular permeability in the kidney glomerulus.

  title={Determinants of vascular permeability in the kidney glomerulus.},
  author={Yuki Hamano and James A Grunkemeyer and Akulapalli Sudhakar and Michael Zeisberg and Dominic Cosgrove and Roy Morello and Brendan Lee and Hikaru Sugimoto and Raghu Kalluri},
  journal={The Journal of biological chemistry},
  volume={277 34},
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the human mutations in nephrin, podocin, alpha-actinin-4, COL4A3, and COL4A5 genes expressed in the glomeruli have been implicated to cause alterations in glomerular filtration apparatus. Nevertheless, the expression of these… CONTINUE READING


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