Determinants of the ubiquitin-mediated degradation of the Met4 transcription factor.

@article{Menant2006DeterminantsOT,
  title={Determinants of the ubiquitin-mediated degradation of the Met4 transcription factor.},
  author={Alexandra Menant and Peggy Baudouin-Cornu and Caroline Peyraud and Mike Tyers and Dominique C. Thomas},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 17},
  pages={
          11744-54
        }
}
In yeast, the Met4 transcription factor and its cofactors Cbf1, Met28, Met31, and Met32 control the expression of sulfur metabolism and oxidative stress response genes. Met4 activity is tuned to nutrient and oxidative stress conditions by the SCF(Met30) ubiquitin ligase. The mechanism whereby SCF(Met30)-dependent ubiquitylation of Met4 controls Met4 activity remains contentious. Here, we have demonstrated that intracellular cysteine levels dictate the degradation of Met4 in vivo, as shown by… CONTINUE READING
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