Determinants of the selective toxicity of alloxan to the pancreatic B cell.

@article{Malaisse1982DeterminantsOT,
  title={Determinants of the selective toxicity of alloxan to the pancreatic B cell.},
  author={Willy Jean Malaisse and Francine Malaisse-Lagae and Abdullah Sener and Daniel G. Pipeleers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 3},
  pages={927-30}
}
The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the resistance to exogenous peroxide were approximately 20 times higher in liver and kidney than in islets, intermediate values being found in exocrine pancreas and muscle. These findings suggest that the… CONTINUE READING

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Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle .
Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle .
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