Determinants of the endosomal localization of sorting nexin 1.

  title={Determinants of the endosomal localization of sorting nexin 1.},
  author={Qi Zhong and Martin J Watson and Cheri S. Lazar and Andrea M. Hounslow and J. P. Waltho and Gordon N. Gill},
  journal={Molecular biology of the cell},
  volume={16 4},
The sorting nexin (SNX) family of proteins is characterized by sequence-related phox homology (PX) domains. A minority of PX domains bind with high affinity to phosphatidylinositol 3-phosphate [PI(3)P], whereas the majority of PX domains exhibit low affinity that is insufficient to target them to vesicles. SNX1 is located on endosomes, but its low affinity PX domain fails to localize in vivo. The NMR structure of the PX domain of SNX1 reveals an overall fold that is similar to high-affinity PX… CONTINUE READING

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