Determinants of the degree of functional mitral regurgitation in patients with systolic left ventricular dysfunction: A quantitative clinical study.

@article{Yiu2000DeterminantsOT,
  title={Determinants of the degree of functional mitral regurgitation in patients with systolic left ventricular dysfunction: A quantitative clinical study.},
  author={Siuming Yiu and Maurice E. Enriquez-Sarano and Ch Tribouilloy and James B. Seward and A Jamil Tajik},
  journal={Circulation},
  year={2000},
  volume={102 12},
  pages={1400-6}
}
BACKGROUND Functional mitral regurgitation (FMR) occurs with a structurally normal valve as a complication of systolic left ventricular dysfunction (LVD). Determinants of degree of FMR are poorly defined; thus, mechanistic therapeutic approaches to FMR are hindered. METHODS AND RESULTS In a prospective study of 21 control subjects and 128 patients with LVD (defined as ejection fraction <50%, mean 31+/-9%) in sinus rhythm, we quantified simultaneously by echocardiography the effective… CONTINUE READING
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