Determinants of the Substrate Specificity of Multidrug Resistance Protein 1

  title={Determinants of the Substrate Specificity of Multidrug Resistance Protein 1},
  author={D. Zhang and S. Cole and R. G. Deeley},
  journal={The Journal of Biological Chemistry},
  pages={20934 - 20941}
  • D. Zhang, S. Cole, R. G. Deeley
  • Published 2002
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Human multidrug resistance protein 1 (MRP1) confers resistance to many natural product chemotherapeutic agents and actively transports structurally diverse organic anion conjugates. We previously demonstrated that two hydrogen-bonding amino acid residues in the predicted transmembrane 17 (TM17) of MRP1, Thr1242 and Trp1246, were important for drug resistance and 17β-estradiol 17-(β-d-glucuronide) (E217βG) transport. To determine whether other residues with hydrogen bonding potential within TM17… CONTINUE READING
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