Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.

  title={Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.},
  author={Emmanuel Bourinet and Tuck Wah Soong and Antony Stea and Terrance P. Snutch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 4},
The modulation of a family of cloned neuronal calcium channels by stimulation of a coexpressed mu opioid receptor was studied by transient expression in Xenopus oocytes. Activation of the morphine receptor with the synthetic enkephalin [D-Ala2,N-Me-Phe4,Gly-ol5]enkephalin (DAMGO) resulted in a rapid inhibition of alpha1A (by approximately 20%) and alpha1B (by approximately 55%) currents while alpha1C and alpha1E currents were not significantly affected. The opioid-induced effects on alpha1A and… CONTINUE READING
Highly Cited
This paper has 65 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 77 citations

66 Citations

Citations per Year
Semantic Scholar estimates that this publication has 66 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-2 of 2 references

Bourinet et al

  • M. DeWaard, D. R. Witcher, +4 authors 12056–12064. Pharmacology
  • Proc. Natl. Acad. Sci. USA 93
  • 1996
1 Excerpt

Handbook of Receptors and Channels: Ligand- and Voltage-Gated Ion Channels, ed

  • A. Stea, T. W. Soong, T. P. Snutch
  • North R. A. (CRC,
  • 1995
1 Excerpt