Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.

@article{Bourinet1996DeterminantsOT,
  title={Determinants of the G protein-dependent opioid modulation of neuronal calcium channels.},
  author={Emmanuel Bourinet and Tuck Wah Soong and Antony Stea and Terrance P. Snutch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 4},
  pages={
          1486-91
        }
}
The modulation of a family of cloned neuronal calcium channels by stimulation of a coexpressed mu opioid receptor was studied by transient expression in Xenopus oocytes. Activation of the morphine receptor with the synthetic enkephalin [D-Ala2,N-Me-Phe4,Gly-ol5]enkephalin (DAMGO) resulted in a rapid inhibition of alpha1A (by approximately 20%) and alpha1B (by approximately 55%) currents while alpha1C and alpha1E currents were not significantly affected. The opioid-induced effects on alpha1A and… CONTINUE READING
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