Determinants of the B-cell response against a transgenic autoantigen

  • DOUGLAS HANAHANt

Abstract

The failure to induce self-tolerance of simian virus 40 large tumor antigen (T antigen) expressed in the pancreatic (3 cells of transgenic mice results in an autoimmune response against this protein and the cells that synthesize it. In every transgenic mouse with delayed onset of T-antigen expression and consequent nontolerance, B cells, T cells, and… (More)

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4 Figures and Tables