Determinants of subcellular localization of the rubella virus nonstructural replicase proteins.

@article{Matthews2009DeterminantsOS,
  title={Determinants of subcellular localization of the rubella virus nonstructural replicase proteins.},
  author={Jason D Matthews and W P Tzeng and Teryl K. Frey},
  journal={Virology},
  year={2009},
  volume={390 2},
  pages={315-23}
}
The rubella virus (RUBV) nonstructural replicase proteins (NSPs), P150 and P90, are proteolytically processed from a P200 precursor. To understand the NSPs' function in the establishment of virus RNA replication complexes (RCs), the NSPs were analyzed in virus-infected cells or cells transfected with NSP-expressing plasmids. In infected cells, P150 was localized in cytoplasmic foci at 24 hpi and in cytoplasmic fibers, unique to RUBV, by 48 hpi. RCs, marked by dsRNA, colocalized with P150-foci… CONTINUE READING

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