Determinants of specificity in TGF-beta signal transduction.

  title={Determinants of specificity in TGF-beta signal transduction.},
  author={Y G Chen and Akiko Hata and Roger S. Lo and David Wotton and Youheng Shi and Nikola P. Pavletich and Joan Massagu{\'e}},
  journal={Genes & development},
  volume={12 14},
Signal transduction by the TGF-beta family involves sets of receptor serine/threonine kinases, Smad proteins that act as receptor substrates, and Smad-associated transcription factors that target specific genes. We have identified discrete structural elements that dictate the selective interactions between receptors and Smads and between Smads and transcription factors in the TGF-beta and BMP pathways. A cluster of four residues in the L45 loop of the type I receptor kinase domain, and a… CONTINUE READING


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