Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors.

@article{Harvey1997DeterminantsOS,
  title={Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors.},
  author={Scott C. Harvey and John McIntosh and Gabriel Cartier and Floyd N Maddox and Charles W Luetje},
  journal={Molecular pharmacology},
  year={1997},
  volume={51 2},
  pages={336-42}
}
The competitive antagonist alpha-conotoxin-MII (alpha-CTx-MII) is highly selective for the alpha3beta2 neuronal nicotinic receptor. Other receptor subunit combinations (alpha2beta2, alpha4beta2, alpha3beta4) are >200-fold less sensitive to blockade by this toxin. Using chimeric and mutant subunits, we identified amino acid residues of alpha3 and beta2 that participate in determination of alpha-CTx-MII sensitivity. Chimeric alpha subunits, constructed from the alpha3 and alpha4 subunits, as well… CONTINUE READING

From This Paper

Topics from this paper.
34 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…