Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells.

Abstract

The cytotoxicity and metabolism of 1-beta-D-arabinofuranosylcytosine (AraC) and its effects on DNA synthesis and integrity were studied in HCT 116 and NCI-H630 human colon cancer cells. In 116 cells, 0.1 microM AraC decreased colony formation by approximately 50%, whereas 1 microM was required in H630 cells. AraCTP levels after a 24-hr AraC exposure were 2… (More)

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@article{Grem1995DeterminantsOS, title={Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells.}, author={Jean L Grem and Francois J Geoffroy and Pedro M. Politi and Dennis P. Cuddy and Dennis Ross and D. Nguyen and Seth Steinberg and Claudio Allegra}, journal={Molecular pharmacology}, year={1995}, volume={48 2}, pages={305-15} }