Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases.

@article{Vu2014DeterminantsOR,
  title={Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases.},
  author={Van V. Vu and William T. Beeson and Christopher M Phillips and Jamie H D Cate and Michael A Marletta},
  journal={Journal of the American Chemical Society},
  year={2014},
  volume={136 2},
  pages={562-5}
}
The ubiquitous fungal polysaccharide monooxygenases (PMOs) (also known as GH61 proteins, LPMOs, and AA9 proteins) are structurally related but have significant variation in sequence. A heterologous expression method in Neurospora crassa was developed as a step toward connecting regioselectivity of the chemistry to PMO phylogeny. Activity assays, as well as sequence and phylogenetic analyses, showed that the majority of fungal PMOs fall into three major groups with distinctive active site… CONTINUE READING
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