Determinants of reduced health-related quality of life in pediatric inherited neuropathies.

@article{Burns2010DeterminantsOR,
  title={Determinants of reduced health-related quality of life in pediatric inherited neuropathies.},
  author={Jaclynne Burns and Sindhu Ramchandren and Monique M. Ryan and Michael E. Shy and Robert A. Ouvrier},
  journal={Neurology},
  year={2010},
  volume={75 8},
  pages={
          726-31
        }
}
OBJECTIVE We have shown that health-related quality of life (QOL) in children with inherited neuropathies (Charcot-Marie-Tooth disease [CMT]) is significantly reduced compared to population norms, thus establishing its utility as an outcome measure in therapeutic trials. However, the Australian ascorbic acid trial in children with CMT type 1A (CMT1A) identified no change in QOL scores despite a trend toward improvement in nerve conduction velocities in the treated group. The objective of this… CONTINUE READING
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