Determinants of rate variation in mammalian DNA sequence evolution

  title={Determinants of rate variation in mammalian DNA sequence evolution},
  author={Lindell Bromham and Andrew Rambaut and P. H. Harvey},
  journal={Journal of Molecular Evolution},
Attempts to analyze variation in the rates of molecular evolution among mammalian lineages have been hampered by paucity of data and by nonindependent comparisons. Using phylogenetically independent comparisons, we test three explanations for rate variation which predict correlations between rate variation and generation time, metabolic rate, and body size. Mitochondrial and nuclear genes, protein coding, rRNA, and nontranslated sequences from 61 mammal species representing 14 orders are used… CONTINUE READING

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