Determinants of protein function revealed by combinatorial entropy optimization

@article{Reva2007DeterminantsOP,
  title={Determinants of protein function revealed by combinatorial entropy optimization},
  author={Boris A. Reva and Yevgeniy Antipin and Chris Sander},
  journal={Genome Biology},
  year={2007},
  volume={8},
  pages={R232 - R232}
}
We use a new algorithm (combinatorial entropy optimization [CEO]) to identify specificity residues and functional subfamilies in sets of proteins related by evolution. Specificity residues are conserved within a subfamily but differ between subfamilies, and they typically encode functional diversity. We obtain good agreement between predicted specificity residues and experimentally known functional residues in protein interfaces. Such predicted functional determinants are useful for… CONTINUE READING

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