Determinants of prognosis of COPD in the elderly: mucus hypersecretion, infections, cardiovascular comorbidity

@article{Pistelli2003DeterminantsOP,
  title={Determinants of prognosis of COPD in the elderly: mucus hypersecretion, infections, cardiovascular comorbidity},
  author={Riccardo Pistelli and Peter Lange and D. L. Miller},
  journal={European Respiratory Journal},
  year={2003},
  volume={21},
  pages={10s - 14s}
}
In this paper, the authors update the present knowledge about three risk factors for the prognosis of chronic obstructive pulmonary disease (COPD), which may be particularly relevant in elderly people: mucus hypersecretion, respiratory infections, and cardiovascular comorbidity. Chronic mucus hypersecretion (CMH) is a common respiratory symptom in old age, the relevance of which is analysed on the basis of data collected during the first three rounds of the Copenhagen City Heart Study. In… Expand
Prognostic Factors in Chronic Obstructive Pulmonary Disease
TLDR
These newly identified prognostic factors are of great interest in that it may be possible to moderate their influence, a circumstance that highlights the need to change the traditional treatment approach and devise therapeutic interventions oriented towards reversing the effects of these factors. Expand
[Prognostic factors in chronic obstructive pulmonary disease].
TLDR
These newly identified prognostic factors are of great interest in that it may be possible to moderate their influence, a circumstance that highlights the need to change the traditional treatment approach and devise therapeutic interventions oriented towards reversing the effects of these factors. Expand
Lung function decline and outcomes in an adult population.
TLDR
Rapid lung function decline was independently associated with a modest increased risk of COPD hospitalizations and deaths and the strongest risk factors for not having a follow-up spirometry were having Global Initiative for Chronic Obstructive Lung Disease stage 3 or 4 disease at baseline. Expand
Effectiveness of erdosteine in elderly patients with bronchiectasis and hypersecretion: a 15-day, prospective, parallel, open-label, pilot study.
TLDR
A regimen of PO erdosteine 225 mg BID in addition to routine chest physiotherapy provided some physiologic and clinical benefits in the treatment of these elderly patients with bronchiectasis and chronic mucus hyper-secretion. Expand
Lung function decline and outcomes in an elderly population
TLDR
Being in the most rapidly declining quartile of FEV1 from baseline to year 4 was associated with an increased risk of admission to hospital for COPD and all-cause death over an additional 7 years of follow up. Expand
Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort
TLDR
A crude association between lung function impairment and prevalent and incident or recurrent CVD that was greatly reduced after adjusting for covariates, including age, sex, race, smoking, comorbid hypertension and diabetes, cholesterol levels and fibrinogen level is observed. Expand
Characteristics of hospitalised patients with COPD in the Nordic countries
TLDR
Substantial differences in the characteristics and management of hospitalised COPD patients between departments of respiratory disease in five Nordic university hospitals are revealed and living alone, concurrent diseases like diabetes and long-term oxygen therapy are predictors of more prolonged hospitalisation periods. Expand
Isolated Acute Right Ventricular Myocardial Infarction and Ischemia in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease
TLDR
The results indicate that patients with exacerbation of COPD are at risk of isolated RV ischemia and infarction, and V3R and V4R lead should be taken. Expand
Emerging drugs for the treatment of chronic obstructive pulmonary disease
TLDR
The molecular rationale for emerging drugs that attack various targets in the inflammatory cascade in chronic obstructive pulmonary disease and their potential efficacy in COPD are reviewed. Expand
Respiratory symptoms/diseases, impaired lung function, and drug use in two Italian general population samples.
TLDR
Most people in the general population do not use drugs, in spite of reported respiratory disorders, and the underuse of medicines seems lower in the urban area than in the rural area. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 64 REFERENCES
Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group.
TLDR
Chronic mucus hypersecretion was significantly and consistently associated with both an excess FEV1 decline and an increased risk of subsequent hospitalization because of COPD. Expand
Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease.
TLDR
Co-morbid diseases and electrocardiogram signs of right ventricular hypertrophy play a major prognostic role in advanced chronic obstructive pulmonary disease and the clinical assessment of patients with chronic obstructives pulmonary disease should include these important and easily measurable variables. Expand
Electrocardiographic signs of chronic cor pulmonale: A negative prognostic finding in chronic obstructive pulmonary disease.
TLDR
Some ECG signs of CCP and PAO2-PaO2 >48 mm Hg during oxygen therapy qualified as a simple and inexpensive tool for targeting subsets of COPD patients with severe or very severe short-term prognosis. Expand
Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease.
TLDR
Patients with acutely exacerbated COPD having a high risk of death can be identified at the time of admission and Variables reflecting heart dysfunction are important determinants of this risk. Expand
Prevalence and Correlates of Respiratory Symptoms and Disease in the Elderly
TLDR
It is concluded that DOE and attacks of wheezing with dyspnea are commonly associated with cardiovascular disease and a low FEV 1 in those over 65 years and that airways obstruction frequently remains undiagnosed in the elderly. Expand
Prevalence and correlates of respiratory symptoms and disease in the elderly. Cardiovascular Health Study.
TLDR
It is concluded that DOE and attacks of wheezing with dyspnea are commonly associated with cardiovascular disease and a low FEV1 in those over 65 years and that airways obstruction frequently remains undiagnosed in the elderly. Expand
Chronic cough in young adults in relation to smoking habits, childhood environment and chest illness.
TLDR
The prevalence of cough increased between the ages of 20 and 25 among those who smoked throughout or who started to smoke during this period and declined for those who never smoked and for thosewho were smoking at 20 but had given up by 25. Expand
Community-acquired pneumonia in old age: a prospective study of 91 patients admitted from home.
TLDR
CAP has more serious clinical and abnormal laboratory features in the elderly than younger patients, particularly in those over 75, and initial antibiotic treatment for these patients should include a macrolide. Expand
Airborne particles are a risk factor for hospital admissions for heart and lung disease.
TLDR
The results were stable when controlling for confounding by sulfur dioxide, ozone, and carbon monoxide, and the results were consistent with previous epidemiology and recent mechanistic studies in animals and humans. Expand
Community acquired pneumonia in elderly people
TLDR
Pneumonia due to atypical pathogens has been considered uncommon in old people: a review of 11 studies of pneumonia identified Chlamydia and Coxiella spp as the cause in only 2% of patients. Expand
...
1
2
3
4
5
...