Determinants of plasma uric acid

  title={Determinants of plasma uric acid},
  author={C. L. Gulbrandsen and Newton E. Morton and D. Chandrasekhar Rao and George G. Rhoads and Abraham Kagan},
  journal={Human Genetics},
Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied. 
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