Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.

@article{Tangy1991DeterminantsOP,
  title={Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.},
  author={Frederic Tangy and A. Stratton McAllister and Christine Aubert and Michel Brahic},
  journal={Journal of virology},
  year={1991},
  volume={65 3},
  pages={1616-8}
}
The DA strain of Theiler's virus persists in the central nervous systems of mice and causes chronic inflammation and demyelination. The GDVII strain, on the other hand, causes an acute encephalitis that kills the host in a matter of days. We constructed a series of recombinants between two infectious cDNA clones of the genomes of DA and GDVII viruses… CONTINUE READING