Determinants of pancreatic islet development in mice and men: a focus on the role of transcription factors.

@article{Lin2012DeterminantsOP,
  title={Determinants of pancreatic islet development in mice and men: a focus on the role of transcription factors.},
  author={Chia-Lei Lin and Patricia Myriam Vuguin},
  journal={Hormone research in paediatrics},
  year={2012},
  volume={77 4},
  pages={205-13}
}
The development of the endocrine pancreas is regulated by several cell-matrix interactions that generate a diverse array of intracellular signals determining the progression of a multipotent progenitor to a mature endocrine cell. This process involves interactions between the epithelium, mesenchyma, and endothelial cells. Later in development, coordinated signaling contributes to the maintenance of the differentiated endocrine cell phenotype. It has been demonstrated that key factors as well as… CONTINUE READING