Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis.

  title={Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis.},
  author={Daniel W Cramer and William R. Welch},
  journal={Journal of the National Cancer Institute},
  volume={71 4},
  • D. Cramer, W. Welch
  • Published 1983
  • Biology, Medicine
  • Journal of the National Cancer Institute
Entrapment of surface epithelium within the ovarian stroma was proposed as an initial event in the pathogenesis of cystadenocarcinoma of the ovary. Subsequent events, including differentiation, proliferation, and eventual malignant transformation of the entrapped epithelium, may occur as a consequence of stimulation by estrogen or estrogen precursors. These events were more likely when the steroid producing stroma itself had been stimulated by high gonadotropins. Animal experiments suggested… Expand
Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone.
  • H. Risch
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 1998
The purpose of this review is to evaluate evidence for and against the incessant ovulation and gonadotropin hypotheses, as well as to consider the possibility that risk of ovarian cancer may be increased by factors associated with excess androgenic stimulation of ovarian epithelial cells and may be decreased by factors related to greater progesterone stimulation. Expand
Growth regulation of ovarian cancer.
The concept that growth stimulatory substances, by their impact on mitosis and cell number, may influence the rate of mutations that could confer malignant transformation serves as an additional mechanism by which growth stimulatories substances can influence ovarian cancer initiation. Expand
Loss of ovarian function and the risk of ovarian cancer
Animal models with premature ovarian failure resulting from the loss or depletion of germ cells consistently develop ovarian surface epithelial cell hyperplasia with invasion into the stroma and theExpand
Endocrine signaling in ovarian surface epithelium and cancer.
There is increasing evidence suggesting that several key reproductive hormones, such as GnRH, gonadotrophins and sex steroids, regulate the growth of normal OSE and ovarian cancer cells and the effects of these endocrine factors on ovarian cancer cell growth are highlighted. Expand
CHAPTER 36 – Ovarian Carcinogenesis
This chapter describes some of the experimental models, both in vivo and in vitro, that are being used to investigate the early events associated with neoplastic transformation of the ovarian surface epithelium. Expand
Possible role of ovarian epithelial inflammation in ovarian cancer.
The possibility that inflammation is a pathophysiologic contributor to the development of ovarian cancer suggests a directed approach to future research. Expand
Gonadotropins and ovarian cancer.
The presence of gonadotropins in ovarian tumor fluid suggests the importance of these factors in the transformation and progression of ovarian cancers as well as being prognostic indicators. Expand
Etiologic Mechanisms in Epithelial Ovarian Cancer
The purpose of this chapter is to consider evidence for and against the two main etiologic hypotheses, concerning incessant ovulation and excessive gonadotropins. Expand
The role of reproductive hormones in epithelial ovarian carcinogenesis.
The role of reproductive hormones in influencing the immune system and tipping the balance against or in favor of developing ovarian cancer is discussed and comment on animal models that are critical for experimentally validating existing hypotheses in key areas of endocrine research and useful for preclinical drug development are commented on. Expand
Ovarian cancer aetiology: facts and fiction
The incessant ovulation theory suggests that the risk of ovarian carcinoma increases as a result of the recurrent minor trauma to the ovarian surface epithelium that occurs during ovulation. TheExpand