Determinants of molecular motor directionality

@article{Endow1999DeterminantsOM,
  title={Determinants of molecular motor directionality},
  author={Sharyn Anne Endow},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={E163-E167}
}
Work over the past two years has led to a breakthrough in our understanding of the molecular basis of the directionality of the kinesin motor proteins. This breakthrough has come first from the reversal of directionality of the kinesin-related motor Ncd, followed closely by the reversal of kinesin’s directionality and the finding that the Ncd ‘neck’ can convert Ncd or kinesin, which are intrinsically plus-end-directed microtubule motors, into a minus-end motor. These findings raise several… CONTINUE READING

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