Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration.

Abstract

Diverse patterns of Ca(2+)(i) release differentially regulate Ca(2+)-sensitive enzymes and gene transcription, and generally the extent of agonist activation of phospholipase C-linked G protein-coupled receptors determines the type of Ca(2+) signal. We have studied global Ca(2+) oscillations arising through activation of the metabotropic glutamate receptor… (More)

Topics

9 Figures and Tables

Cite this paper

@article{Nash2002DeterminantsOM, title={Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration.}, author={Mark S Nash and Michael J. Schell and Peter J. Atkinson and Neil Russell Johnston and Stefan R. Nahorski and R. A. John Challiss}, journal={The Journal of biological chemistry}, year={2002}, volume={277 39}, pages={35947-60} }