Determinants of membrane protein topology.

  title={Determinants of membrane protein topology.},
  author={D. H. A. Boyd and Colin S Manoil and Jon et Beckwith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 23},
The topology of the integral membrane protein MalF, which is required for maltose transport in Escherichia coli, has been analyzed using fusions of alkaline phosphatase (EC The properties of such fusion strains support a MalF structure previously proposed on theoretical grounds. Several transmembrane segments within MalF can act as signal sequences in exporting alkaline phosphatase. Other transmembrane sequences, in conjunction with cytoplasmic domains, can stably anchor alkaline… CONTINUE READING


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