Determinants of lipid levels among children with heterozygous familial hypercholesterolemia in Norway.

@article{Tonstad1995DeterminantsOL,
  title={Determinants of lipid levels among children with heterozygous familial hypercholesterolemia in Norway.},
  author={Serena Tonstad and Trond P. Leren and Mette Sivertsen and Leiv Ose},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1995},
  volume={15 8},
  pages={1009-14}
}
Three founder mutations have been discovered among individuals with familial hypercholesterolemia (FH) in Norway: FHElverum and FHSvartor, predicted to be null alleles, and FHC210G, predicted to disrupt the secondary structure of the ligand-binding domain. To clarify the effect of these and other mutations on lipid levels and parental history of premature cardiovascular disease, we examined 164 boys and girls ages 6 to 16 years with heterozygous FH. Among all children, serum cholesterol levels… CONTINUE READING

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