Determinants of human plasma glutathione peroxidase (GPx-3) expression.

  title={Determinants of human plasma glutathione peroxidase (GPx-3) expression.},
  author={Charlene Bierl and Barbara Voetsch and Richard C. Jin and Diane E. Handy and Joseph Loscalzo},
  journal={The Journal of biological chemistry},
  volume={279 26},
Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. GPx-3 deficiency has been associated with cardiovascular disease and stroke. The regulation of GPx-3 expression remains largely uncharacterized, however, and we studied its transcriptional and translational determinants in a cultured cell system. In transient transfections of a renal cell line (Caki-2), the published sequence cloned upstream of a luciferase reporter gene produced minimal… CONTINUE READING
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