Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions.

@article{Sherman2003DeterminantsOH,
  title={Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions.},
  author={Mark E. Sherman and Sophia Wang and Cosette Marie Wheeler and Laurie Rich and Patti Gravitt and Robert E. Tarone and Mark Schiffman},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2003},
  volume={12 10},
  pages={1038-44}
}
Measurement of human papillomavirus (HPV) DNA load has been suggested as a means for improving the positive predictive value of HPV testing for detecting cervical intraepithelial neoplasia 3 and cancer (CIN3+). We hypothesized that lesions surrounding CIN3+ (especially the extent of associated CIN1) are important determinants of load, which limit its clinical use. To test this hypothesis, we reviewed the pathology of women at enrollment in the Atypical Squamous Cells of Undetermined… CONTINUE READING
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A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation

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