Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.

@article{Laciski2004DeterminantsOH,
  title={Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.},
  author={Mariusz Laciński and Wlodzimierz Skorupski and Andrzej Cieśliński and Joanna Sokolowska and Wieslaw Henryk Trzeciak and Hieronim Jakubowski},
  journal={Cellular and molecular biology},
  year={2004},
  volume={50 8},
  pages={885-93}
}
Homocysteine (Hcy)-thiolactonase (HTase) activity of the paraoxonase-1 (PON1) protein detoxifies Hcy-thiolactone in human blood and could thus delay the development of atherosclerosis. To gain insight into physiological role(s) of the PON1 protein, we studied HTase activities and PON1 genotypes in a group of 184 subjects, 32.6% of whom were healthy, 27.7% had angiographically proven coronary artery disease but did not have myocardial infarction (CAD), and 39.7% had myocardial infarction (MI… CONTINUE READING

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