Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains

@article{Kim1995DeterminantsOH,
  title={Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains},
  author={J. Kim and Kevin Struhl},
  journal={Nucleic acids research},
  year={1995},
  volume={23 13},
  pages={2531-7}
}
The AP-1 and ATF/CREB families of eukaryotic transcription factors are dimeric DNA-binding proteins that contain the bZIP structural motif. The AP-1 and ATF/CREB proteins are structurally related and recognize identical half-sites (TGAC), but they differ in their requirements for half-site spacing. AP-1 proteins such as yeast GCN4 preferentially bind to sequences with overlapping half-sites, whereas ATF/CREB proteins bind exclusively to sequences with adjacent half-sites. Here we investigate… CONTINUE READING
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