Determinants of genetic diversity

@article{Ellegren2016DeterminantsOG,
  title={Determinants of genetic diversity},
  author={Hans Ellegren and Nicolas Galtier},
  journal={Nature Reviews Genetics},
  year={2016},
  volume={17},
  pages={422-433}
}
Genetic polymorphism varies among species and within genomes, and has important implications for the evolution and conservation of species. The determinants of this variation have been poorly understood, but population genomic data from a wide range of organisms now make it possible to delineate the underlying evolutionary processes, notably how variation in the effective population size (Ne) governs genetic diversity. Comparative population genomics is on its way to providing a solution to… Expand
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References

SHOWING 1-10 OF 194 REFERENCES
Comparative population genomics in animals uncovers the determinants of genetic diversity
TLDR
It is shown that the diversity of a species is predictable, and is determined in the first place by its ecological strategy, and demonstrates the influence of long-term life-history strategies on species response to short-term environmental perturbations. Expand
Does linked selection explain the narrow range of genetic diversity across species?
TLDR
Evidence that linked selection strongly constrains levels of polymorphism in species with large census sizes is found and weak support for this conclusion is found. Expand
Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans
TLDR
A population genetic analysis of Drosophila simulans is presented based on whole-genome shotgun sequencing of multiple inbred lines and comparison of the resulting data to genome assemblies of the closely related species, D. melanogaster and D. yakuba, to suggest several new hypotheses regarding the genetic and biological mechanisms controlling polymorphism and divergence across the Drosophile genome. Expand
Pervasive Natural Selection in the Drosophila Genome?
TLDR
Analyses of genetic variation within and between species reveal that much of the Drosophila genome is under purifying selection, and thus of functional importance, and that a large fraction of coding and noncoding differences between species are adaptive. Expand
Natural Selection Constrains Neutral Diversity across A Wide Range of Species
TLDR
It is demonstrated that natural selection removes more variation at linked neutral sites in species with large Nc than those with small Nc and provides direct empirical evidence thatnatural selection constrains levels of neutral genetic diversity across many species. Expand
Quantifying the Variation in the Effective Population Size Within a Genome
TLDR
The amount of variation in the effective population size is quite modest in all species and it is shown that most genes have an Ne that is within a few fold of all other genes, which is sufficient to cause significant differences in the efficiency of natural selection across the genome. Expand
The impact of linked selection on plant genomic variation
  • T. Slotte
  • Biology, Medicine
  • Briefings in functional genomics
  • 2014
TLDR
The impact of genome architecture and mating system on the expected signature of linked selection in plants is discussed and empirical evidence for linked selection is reviewed, with a focus on plant model systems. Expand
Genomic signatures of selection at linked sites: unifying the disparity among species
TLDR
The dominant features that could drive differences in linked selection among species are characterized — including roles for selective sweeps being 'hard' or 'soft' — and the concealing effects of demography and confounding genomic variables are characterized. Expand
Effective population size and patterns of molecular evolution and variation
TLDR
The properties of Ne are reviewed in a variety of different situations of biological interest, and advances in genomic techniques are giving new insights into how selection shapes Ne. Expand
Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae.
TLDR
It is concluded that the positive relation between nucleotide polymorphism and the rate of crossover represents the footprint of natural selection across the C. briggsae genome and that background selection against deleterious mutations is sufficient to explain this pattern. Expand
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...