Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning stimulus painfulness, gender and personality variables matter?

@article{Granot2008DeterminantsOE,
  title={Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning stimulus painfulness, gender and personality variables matter?},
  author={Michal Granot and Irit Weissman-Fogel and Yonathan Crispel and Dorit Pud and Yelena Granovsky and Elliot Sprecher and David Yarnitsky},
  journal={Pain},
  year={2008},
  volume={136 1-2},
  pages={142-9}
}
Descending modulation of pain can be demonstrated psychophysically by dual pain stimulation. This study evaluates in 31 healthy subjects the association between parameters of the conditioning stimulus, gender and personality, and the endogenous analgesia (EA) extent assessed by diffuse noxious inhibitory control (DNIC) paradigm. Contact heat pain was applied as the test stimulus to the non-dominant forearm, with stimulation temperature at a psychophysical intensity score of 60 on a 0-100… CONTINUE READING