Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients.

@article{OcamposMartinez2012DeterminantsOE,
  title={Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients.},
  author={Eva Ocampos-Martinez and Laura Penaccini and Sabino Scolletta and Ali Abdelhadii and A Devigili and Silvia Cianferoni and Daniel De Backer and Fr{\'e}d{\'e}rique Jacobs and Frederic J Cotton and J K Vincent and Fabio Silvio Taccone},
  journal={International journal of antimicrobial agents},
  year={2012},
  volume={39 4},
  pages={332-7}
}
Vancomycin is frequently administered to critically ill patients by continuous infusion in order to optimise drug efficacy; however, there are few data available on the efficacy of this strategy in septic patients. In this retrospective analysis, 261 patients treated with continuous infusion of vancomycin in the Department of Intensive Care at Hôpital Erasme (Brussels, Belgium) were evaluated. Creatinine clearance (CL(Cr)) was calculated from 24-h urine collection and normalised to body surface… CONTINUE READING