Determinants of disease phenotype in trypanosomatid parasites.

@article{McCall2014DeterminantsOD,
  title={Determinants of disease phenotype in trypanosomatid parasites.},
  author={Laura-Isobel McCall and James H McKerrow},
  journal={Trends in parasitology},
  year={2014},
  volume={30 7},
  pages={342-9}
}
Trypanosomatid parasites infect over 21 million people worldwide, with a range of disease phenotypes. Trypanosoma cruzi causes American trypanosomiasis, wherein 30-40% of infected individuals develop disease manifestations, most commonly cardiomyopathy but also digestive megasyndromes. In the case of Trypanosoma brucei, the etiological agent of African trypanosomiasis, disease progression can be rapid or slow, with early or late central nervous system involvement. Finally, Leishmania species… CONTINUE READING
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