Determinants of deoxyglucose uptake in cultured astrocytes: the role of the sodium pump.

@article{Brookes1985DeterminantsOD,
  title={Determinants of deoxyglucose uptake in cultured astrocytes: the role of the sodium pump.},
  author={Neville Brookes and Paul Yarowsky},
  journal={Journal of neurochemistry},
  year={1985},
  volume={44 2},
  pages={
          473-9
        }
}
Glucose utilization in primary cell cultures of mouse cerebral astrocytes was studied by measuring uptake of tracer concentrations of [3H]2-deoxyglucose ([3H]2-DG). The resting rate of glucose utilization, estimated at an extracellular K+ concentration ([K+]o) of 5.4 mM, was high (7.5 nmol glucose/mg protein/min) and was similar in morphologically undifferentiated and "differentiated" (dibutyryl cyclic AMP-pretreated) cultures. Resting uptake of [3H]2-DG was depressed by ouabain, by reducing [K… CONTINUE READING
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