Determinants of coronary artery reactivity in premenopausal female cynomolgus monkeys with diet-induced atherosclerosis.

@article{Williams1994DeterminantsOC,
  title={Determinants of coronary artery reactivity in premenopausal female cynomolgus monkeys with diet-induced atherosclerosis.},
  author={James Koudy Williams and Carol A. Shively and Thomas B. Clarkson},
  journal={Circulation},
  year={1994},
  volume={90 2},
  pages={983-7}
}
BACKGROUND The purpose of this study was to identify determinants of coronary artery reactivity among premenopausal female monkeys. Estrogen replacement therapy in postmenopausal females modulates reactivity of atherosclerotic coronary arteries. However, no studies have evaluated the factors that modulate coronary artery reactivity among premenopausal females. METHODS AND RESULTS Twenty-five adult premenopausal female monkeys were fed an atherogenic diet for 32 months. During this time… CONTINUE READING