Determinants of Swe1p degradation in Saccharomyces cerevisiae.

@article{McMillan2002DeterminantsOS,
  title={Determinants of Swe1p degradation in Saccharomyces cerevisiae.},
  author={John N. McMillan and Chandra L. Theesfeld and Jacob Harrison and Elaine S. G. Bardes and Daniel J. Lew},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 10},
  pages={
          3560-75
        }
}
Swe1p, the sole Wee1-family kinase in Saccharomyces cerevisiae, is synthesized during late G1 and is then degraded as cells proceed through the cell cycle. However, Swe1p degradation is halted by the morphogenesis checkpoint, which responds to insults that perturb bud formation. The Swe1p stabilization promotes cell cycle arrest through Swe1p-mediated inhibitory phosphorylation of Cdc28p until the cells can recover from the perturbation and resume bud formation. Swe1p degradation involves the… CONTINUE READING

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