Determinants of RasC specificity during Dictyostelium aggregation.

Abstract

RasC is required for optimum activation of adenylyl cyclase A and for aggregate stream formation during the early differentiation of Dictyostelium discoideum. RasG is unable to substitute for this requirement despite its sequence similarity to RasC. A critical question is which amino acids in RasC are required for its specific function. Each of the amino… (More)
DOI: 10.1074/jbc.M110.181115

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