Determinants of HIV-1 shedding in the genital tract of women.

  title={Determinants of HIV-1 shedding in the genital tract of women.},
  author={Andrea A Kovacs and Steven S Wasserman and Dennis K. Burns and David M Wright and Jonathan B. Cohn and Alan L. Landay and Karoline Weber and Myron L. Cohen and Alexandra Levine and Howard Minkoff and Paolo G. Miotti and Joel M Palefsky and Megan L Young and Patricia Reichelderfer},
  volume={358 9293},
BACKGROUND Plasma HIV-1 RNA concentration has been the best predictor for risk of heterosexual and perinatal transmission. However, direct contact with HIV-1 present locally in the genital tract might be necessary for transmission. We aimed to assess the relation between HIV-1 shedding (RNA or culturable virus) in female genital secretions and other factors that might affect HIV-1 shedding. METHODS This was a cross-sectional study within the Women's Interagency HIV Study (WIHS), a prospective… CONTINUE READING