Determinants of F2-isoprostane biosynthesis and inhibition in man.

  title={Determinants of F2-isoprostane biosynthesis and inhibition in man.},
  author={Giovanni Dav{\'i} and A. Ruiz Falc{\'o} and Carlo Patrono},
  journal={Chemistry and physics of lipids},
  volume={128 1-2},
Several cardiovascular risk factors are characterized by the coexistence of low-grade inflammation, enhanced oxidative stress and lipid peroxidation. It has been hypothesized that F2-isoprostanes, a product of in vivo lipid peroxidation, may transduce the effects of metabolic and hemodynamic abnormalities into increased cardiovascular risk. Thus, the formation of these compounds, including urinary 8-iso-Prostaglandin (PG) F2alpha, has been investigated in clinical settings putatively associated… CONTINUE READING


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