Determinants for DNA-binding site recognition by the glucocorticoid receptor.

@article{Zilliacus1992DeterminantsFD,
  title={Determinants for DNA-binding site recognition by the glucocorticoid receptor.},
  author={Johanna Zilliacus and Anthony P. H. Wright and Ulf Norinder and J A Gustafsson and Jan Carlstedt-Duke},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 35},
  pages={24941-7}
}
The glucocorticoid receptor binds with high specificity to glucocorticoid response elements, discriminating them from other closely related binding sites. Three amino acids in the recognition alpha-helix of the DNA-binding domain of the receptor are primarily responsible for this specific DNA binding activity. In this study we analyze in detail how these… CONTINUE READING