Determinant spreading during experimental autoimmune encephalomyelitis: is it potentiating, protecting or participating in the disease?

@article{Kumar1998DeterminantSD,
  title={Determinant spreading during experimental autoimmune encephalomyelitis: is it potentiating, protecting or participating in the disease?},
  author={Vipin Kumar},
  journal={Immunological reviews},
  year={1998},
  volume={164},
  pages={73-80}
}
During many autoimmune conditions, a T-cell response initially focused to a self-antigen evolves towards the recruitment of T cells to multiple antigenic determinants. Here we discuss whether such determinant spreading involves T cells activated in the peripheral lymphoid organs, or alternatively, whether the diversification occurs after infiltration of the initiating T cells into the target organ, for example, into the central nervous system during experimental autoimmune encephalomyelitis, a… CONTINUE READING

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